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Submitted: 14 Nov 2024 | Revision requested: 02 Jan 2025

Under Review

Hippocampal LTP and Memory: A Comprehensive Analysis[Reviewer 2: Title too broad — specify mechanism]

Dr. S. Nakamura¹, J. Okafor², R. Mehta³[Add ORCID IDs — required by journal]

Abstract

The persistence of long-term potentiation (LTP) in hippocampal CA1 neurons has been proposed as a cellular correlate of [Reviewer 1: Quantify "long-term" — define consolidation window explicitly]episodic memory consolidation. In this study, we examine the role of BDNF-TrkB signaling in modulating synaptic tagging (n=48) [increase sample size]and capture (STC) across a 72-hour consolidation window (n=48, p<0.001). Our findings suggest that late-phase LTP maintenance is critically dependent on protein synthesis initiated within the first 4 hours post-induction.

1. Introduction

The molecular mechanisms underlying memory formation have been extensively studied... [cite Bliss & Collingridge 1993]

"Methods section incomplete — add statistical analysis protocol"
"Fig. 3 resolution too low for print"
Raw Manuscript

Journal of Neuroscience Research · Vol. 42, Issue 3

DOI: 10.1523/JNR.2025.42.3.0847 · Published 15 Feb 2025

Open AccessPeer Reviewed

BDNF-TrkB Signaling Governs Late-Phase LTP Maintenance During a Critical 72-Hour Consolidation Window in Hippocampal CA1 Neurons

Sato Nakamura5678Kyoto Univ.
Emeka Okafor4321MIT
Priya Mehta1357Stanford

Abstract

The persistence of long-term potentiation (LTP) in hippocampal CA1 neurons has been proposed as a cellular correlate of episodic memory consolidation. In this study, we examine the role of BDNF-TrkB signaling in modulating synaptic tagging and capture (STC) across a 72-hour consolidation window (n=48, p<0.001). Our findings suggest that late-phase LTP maintenance is critically dependent on protein synthesis initiated within the first 4 hours post-induction.

LTPBDNFMemory ConsolidationHippocampusSynaptic Tagging
47 Citations·Impact Factor 8.24·2,341 Downloads
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